Dental substrate interface

The dental substrate interface denotes the contact zone between a dental material (e.g., composite resin, adhesive, or implant surface) and native tooth tissues (enamel, dentin) or bone. This interface is critically important in dentistry as its physicochemical and biological properties govern restoration longevity, integration, and resistance to microbial colonization and demineralization. At the molecular level, the interface may involve interactions with extracellular matrix proteins (such as SIBLING family proteins), salivary pellicle components (including gp340 and AgI/II from microbes), and intrinsically disordered proteins (IDPs) that mediate mineralization processes[1][2][3]. The behavior of this interface—its susceptibility to biofilm formation, acid attack, and degradation—directly impacts dental diseases like caries and failure modes such as restoration breakdown[1]. While the interface is biochemically active and affected by numerous proteins and cellular responses, "dental substrate interface" itself does not refer to a single protein, receptor, enzyme, or pharmacologically targetable entity.

Other names

Restoration-tooth interfacecomposite-tooth interfaceimplant-tissue interface