Target intelligence / Profile preview

Dentin mineral phase

Molecular classification
Inorganic mineral, Bioceramic, Other
01

Overview

The dentin mineral phase is the inorganic component of dentin, primarily composed of carbonated hydroxyapatite crystals embedded within a collagenous matrix [1]. It constitutes approximately 70% of dentin by weight, providing the essential hardness and structural integrity required for masticatory function while acting as a protective barrier for the underlying dental pulp [2]. In pathological conditions such as dental caries, this mineral phase undergoes demineralization due to organic acids produced by cariogenic bacteria, leading to the breakdown of tooth structure [3]. Therapeutic interventions target the dentin mineral phase to promote remineralization, utilizing agents like fluoride to facilitate the formation of fluorapatite, which is significantly more resistant to acid than the original hydroxyapatite [4][5]. Additionally, the mineral phase is a primary target in the treatment of dentin hypersensitivity, where various agents are applied to occlude exposed dentinal tubules and stabilize the mineral surface [6].

Other names
Dentinal mineralDentin hydroxyapatiteCarbonated hydroxyapatiteTooth mineral phase
02

Mechanism of action

Promotion of remineralization through the formation of fluorapatite, occlusion of dentinal tubules to reduce fluid movement and sensitivity, and enhancement of structural resistance to acid dissolution.

03

Biological functions

Structural supportProtection of dental pulpIon reservoirOther
04

Disease associations

Dental cariesDentin hypersensitivityDentinogenesis imperfectaAcid erosionOther
05

Safety considerations

Dental fluorosisPulp irritationTooth stainingSystemic toxicity from excessive ingestion
06

Interacting drugs

Sodium fluoride

5 more in the full profile.

07

Biomarkers

Mineral densitySurface microhardnessCalcium-to-phosphate ratioCrystallinity index

Beyond the preview

Go deeper on Dentin mineral phase.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Full profile access

Explore the programs pursuing this target and their development progress.

  • Drug candidates
  • Developers
  • Development stage

Clinical trials

Full profile access

Follow the clinical studies evaluating therapies directed at this target.

  • Trial design
  • Status
  • Readouts

Competitive landscape

Full profile access

Compare approaches across drug candidates, modalities, and indications.

  • Programs
  • Modalities
  • Indications

Literature & evidence

Full profile access

Investigate the research and source evidence behind target biology and development.

  • Publications
  • Sources
  • Analysis

Patents

Full profile access

Explore patent activity around therapies and technologies addressing this target.

  • Patents
  • Assignees
  • Technologies

Research & analysis

Full profile access

Connect target biology, drug development, and emerging evidence in your research.

  • Biology
  • Development news
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on Dentin mineral phase.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call