Dentinogenesis stimulation via cytokine induction

Dentinogenesis stimulation via cytokine induction" refers to the process whereby inflammatory cytokines, such as TNF-α, IL-1β, and others, signal to dental pulp stem cells (DPSCs) and odontoblasts to promote their differentiation and the secretion of new dentin, often in response to injury or infection. This reparative pathway involves signaling intermediates such as TrkB and downstream activation of NF-κB and MAPK pathways, resulting in chemokine and growth factor production, immune cell recruitment, and mineralized tissue formation. Clinical interventions, such as the application of calcium hydroxide or mineral trioxide aggregate, may exploit or modify this process for therapeutic pulp capping, but efficacy and outcomes depend on proper modulation of the inflammatory response, as excess or chronic inflammation can lead to pulp necrosis rather than regeneration[1][2][3][4][5][6].

Other names

Dentinogenesis by cytokinesCytokine-induced dentinogenesisReparative dentinogenesis via cytokines

Induction of odontogenic differentiation and dentin reparative processes through signaling intermediates such as TNF-α, IL-1β, and various growth factors (e.g., TGF-β1, BMP-2) activating downstream pathways like NF-κB and MAPK, leading to cell migration and mineral deposition[1][2][3][4]