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Target intelligence / Profile preview
Deoxyhypusine synthase (DHPS)
- Target
- DHPS
- Molecular classification
- Enzyme, Transferase
01
Overview
Deoxyhypusine synthase (DHPS) is an essential enzyme that catalyzes the first step in the post-translational modification of eukaryotic initiation factor 5A (eIF5A), specifically forming deoxyhypusine, a precursor to hypusine—a unique amino acid found only in eIF5A. This modification is critical for the activation and function of eIF5A, which plays a central role in mRNA translation and cellular growth. DHPS is considered a therapeutic target in cancer, diabetes, and infectious diseases.
02
Mechanism of action
Inhibition of DHPS leads to reduced hypusination of eIF5A, thereby impairing mRNA translation and cellular growth/division.
03
Biological functions
Post-translational modificationmRNA translationCellular proliferationCell growthActivation of eukaryotic initiation factor 5A (eIF5A)
04
Disease associations
CancerDiabetes mellitusNeurological disordersImmune disordersAgingInfection
05
Safety considerations
Inhibition of DHPS may affect normal cellular processes due to its essential role in protein synthesis.Off-target effects need to be considered when developing DHPS inhibitors.
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