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Target intelligence / Profile preview
Deoxynucleotidyltransferase terminal-interacting protein 2 (DNTTIP2)
- Target
- DNTTIP2
- Molecular classification
- Other (nuclear protein involved in chromatin remodeling, ribosome biogenesis, RNA binding)
01
Overview
Deoxynucleotidyltransferase terminal-interacting protein 2 (DNTTIP2) is a chromatin-associated nuclear protein implicated in chromatin remodeling and regulation of gene transcription. It enhances the transcriptional activity of estrogen receptor alpha, interacts with terminal deoxynucleotidyltransferase, and is part of the ribosomal SSU processome, contributing to RNA folding, modifications, and cleavage. DNTTIP2 displays essential sequence features for RNA binding and is expressed in various tissues, with a role in RNA processing and organ development. Although not a direct therapeutic target, its expression may serve as a biomarker in chronic lung disease.
- Other names
- ERBPTDIF2LPTS-RP2TdIF2HSU15552FCF2LPTS-interacting protein 2Estrogen receptor-binding proteinTerminal deoxynucleotidyltransferase-interacting factor 2acidic 82 kDa protein mRNA
02
Biological functions
Chromatin remodelingGene transcription regulationEnhancement of estrogen receptor alpha transcriptional activityRNA bindingPart of ribosome biogenesis machinery (SSU processome)RNA processing
03
Disease associations
Chronic obstructive pulmonary disease (biomarker role based on expression profile)Digestive organ development (role shown in zebrafish and inferred from RNA processing functions)Other (potential links to transcriptional misregulation, but no established direct disease causality)
04
Biomarkers
DNTTIP2 expression profile is a potential biomarker for chronic obstructive pulmonary disease
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