Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Deoxyribonuclease 1 (DNase I)
- Target
- DNase I
- Molecular classification
- Enzyme, Endonuclease, Glycoprotein
01
Overview
Deoxyribonuclease 1 (DNase I) is an endonuclease enzyme that catalyzes the hydrolysis of DNA, cleaving phosphodiester bonds to yield fragments with 5'-phosphate and 3'-hydroxyl ends. DNase I acts on both single-stranded and double-stranded DNA, as well as chromatin. It plays several physiological roles, including digesting extracellular nucleoproteins, involvement in apoptosis-related DNA fragmentation, and working alongside DNASE1L3 to degrade neutrophil extracellular traps. Mutations or reduced activity of DNase I have been linked to systemic lupus erythematosus (SLE). Recombinant human DNase I is used therapeutically in cystic fibrosis patients.
02
Mechanism of action
Hydrolyzes DNA phosphodiester bonds
03
Biological functions
Digestion of extracellular DNADigestion of nucleoproteinsApoptosis-related DNA fragmentationNET degradation
04
Disease associations
Systemic Lupus Erythematosus (SLE)Cystic FibrosisAutoimmune disease
Beyond the preview
Go deeper on Deoxyribonuclease 1 (DNase I).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Deoxyribonuclease 1 (DNase I).