Deoxyribonuclease-2-beta (DNASE2B)

Deoxyribonuclease-2-beta (DNASE2B) is a lysosomal endonuclease enzyme that catalyzes the hydrolysis of double-stranded DNA at acidic pH and does not require divalent cations for activity[1][2][6]. It participates in the degradation of nuclear DNA, notably during the differentiation of lens cells in the eye and is mainly expressed in the salivary gland and lungs in humans[1][2][6]. DNASE2B is structurally related to DNASE2, but has a much more restricted tissue expression[1][2][6]. Genetic variants in DNASE2B have been associated with ocular disease, particularly cataract[1]. DNASE2B is part of the DNase2 family of lysosomal enzymes involved in the removal of self-DNA from dying cells and the maintenance of tissue homeostasis[4]. No drugs are currently known to target DNASE2B directly, and its primary characterized function is in physiological DNA clearance rather than pathology or direct therapeutic intervention.

Other names

Deoxyribonuclease II betaDNASE2BDLADDNase II betaDNase II-like acid DNaseDNase2-like acid DNaseEndonuclease DLADlysosomal DNase II