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Target intelligence / Profile preview
Deoxyribonucleic Acid Alkylation (DNA Alkylation)
- Target
- DNA Alkylation
- Molecular classification
- DNA, Nucleic Acid Modification
01
Overview
DNA alkylation is a type of DNA damage resulting from the covalent addition of alkyl groups to DNA bases or the phosphodiester backbone. This modification can disrupt DNA replication and transcription, leading to mutations, cell death, and cancer. It is also a target for several chemotherapeutic agents that induce DNA damage in rapidly dividing cells. Repair mechanisms such as MGMT and BER play a crucial role in mitigating the effects of alkylation.
- Other names
- Alkylated DNADNA AdductsModified DNA
02
Mechanism of action
Covalent modification of DNA bases or phosphodiester backbone, leading to DNA damage, replication block, transcription stalling, and cell death.
03
Biological functions
DNA ReplicationTranscriptionGenome StabilityMutagenesisDNA Repair
04
Disease associations
CancerGenetic DisordersAgingCarcinogenesis
05
Safety considerations
Off-target AlkylationDrug ResistanceSecondary MalignanciesBone Marrow Suppression
06
Interacting drugs
Nitrogen Mustards
3 more in the full profile.
07
Biomarkers
MGMT ExpressionAlkyl DNA Adduct LevelsMicrosatellite InstabilityBER Pathway Activity
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