Deoxyribonucleic acid within target tissue (DNA)

Deoxyribonucleic acid (DNA) is the hereditary material in nearly all living organisms, composed of two antiparallel strands forming a double helix and made up of four types of nucleotides: adenine, thymine, guanine, and cytosine[1][2][3][5]. In eukaryotic cells, DNA is compartmentalized within the cell nucleus and encodes genes that direct all cellular functions, including the synthesis of RNAs and proteins[4]. DNA itself is a target for numerous drugs but is not typically considered a specific "therapeutic target" in the way that proteins such as receptors, enzymes, or transporters are; rather, drugs may target DNA directly to disrupt genetic processes in diseases such as cancer or viral infections. The phrase “cell DNA within target tissue” is nonstandard and does not refer to a specific molecule or protein; instead, it generically denotes all genome DNA present in a given cell or tissue—a concept rather than a discrete target entity. Therefore, it should not be listed as a therapeutic target.

Other names

DNAcell DNAchromosomal DNAgenomic DNA

DNA crosslinking, DNA intercalation, DNA strand breakage, inhibition of DNA synthesis, inhibition of replication enzymes (e.g., topoisomerases)