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Deoxythymidylate kinase (DTYMK)
- Target
- DTYMK
- Molecular classification
- Enzyme, Kinase
01
Overview
Deoxythymidylate kinase (DTYMK) is a pyrimidine metabolic enzyme that catalyzes the phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), a key step in the synthesis of deoxythymidine triphosphate (dTTP), which is essential for DNA replication and repair. DTYMK is vital for cell cycle progression and genome stability; its deficiency causes severe neurodevelopmental diseases, while its overexpression is linked to cancer progression due to increased nucleotide synthesis capacity for rapidly dividing cells[1][2][3].
- Other names
- Thymidylate kinaseTMPKTYMKCDC8dTMP kinasePP3731CONPMKTHY_HUMAN
02
Mechanism of action
Inhibition leads to depletion of dTTP, DNA synthesis impairment, and cell death, particularly in highly proliferative cells such as cancer cells[1][2]
03
Biological functions
Pyrimidine metabolismDNA synthesisCell cycle progressiondTTP biosynthesisDNA repair
04
Disease associations
CancerNeurodegeneration (including childhood-onset with progressive microcephaly and epilepsy)Mitochondrial DNA depletion syndrome
05
Safety considerations
Targeting DTYMK can affect normal proliferating tissues, posing risks of DNA synthesis impairment in normal cells[1][2]
06
Interacting drugs
No direct inhibitors or approved drugs targeting DTYMK are well established; some drugs may modulate its expression[1]
07
Biomarkers
DTYMK expression is a potential prognostic biomarker in several cancers (e.g., hepatocellular carcinoma, lung cancer, colon cancer)[1]
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