Deoxyuridine triphosphatase pseudogene 6 (DUTP6)

Deoxyuridine triphosphatase pseudogene 6 (DUTP6) is annotated as a pseudogene in the human genome, with Ensembl ID ENSG00000225171 and Entrez Gene ID 100873912[1][2]. Pseudogenes such as DUTP6 do not encode a functional protein and lack biological activity as a receptor, enzyme, transporter, or other canonical drug target. DUTP6 is related by sequence to the functional enzyme deoxyuridine triphosphatase (DUT), but there is no evidence of protein expression or therapeutic relevance for DUTP6 itself. Therefore, DUTP6 should not be considered a pharmacologically relevant target, and its inclusion as a drug target would be incorrect. There are multiple deoxyuridine triphosphatase pseudogenes in the human genome; none are interpreted as active molecular targets, and all are classified as genomic pseudogenes rather than functional gene products[1][2][6]. The functional protein deoxyuridine triphosphatase (DUT) is an enzyme involved in nucleotide metabolism and DNA replication, but DUTP6 is only a non-coding pseudogene corresponding by sequence to DUT and carries no known biological or clinical roles[3][4][5]. No drugs, mechanisms of action, disease associations, biomarker utility, or safety concerns have been reported for DUTP6.

Other names

DUTP6