Deoxyuridine triphosphatase pseudogene 8 (DUTP8)

Deoxyuridine triphosphatase pseudogene 8 (DUTP8) is a human genetic locus (Gene ID: 100873914, chromosomal location 4q23) classified as a *pseudogene*. Unlike its functional counterpart, the deoxyuridine triphosphatase (DUT) gene, DUTP8 does not produce a functional enzyme. Pseudogenes such as DUTP8 are genomic sequences similar to known genes but contain substitutions or structural changes (such as early stop codons) that preclude their expression as functional proteins[1][4][5]. While the functional DUT gene product is critical for DNA synthesis and genomic stability—and is a potential therapeutic target implicated in cancer cell resistance to antimetabolites—pseudogene DUTP8 has **no known protein product, biological function, or disease role**, nor is it considered a therapeutic target[1][3][6][5]. Note: If you are looking for the therapeutic target involved in DNA repair and chemotherapy response, refer to the functional **deoxyuridine triphosphatase (DUT)**, not this pseudogene. DUTP8 only shares sequence similarity with the active gene but does not encode an active enzyme or therapeutic target[3][6].

Other names

dUTPase pseudogene 8dUTPase P8DUTP8

None (see above)