Target intelligence / Profile preview

DEP domain containing protein 1 (DEPDC1)

Target: DEPDC1
Molecular classification: Transcription factor, GTPase activator protein

Overview

DEPDC1 is a protein containing a DEP domain and functions as a transcription repressor and GTPase activator. It is overexpressed in various cancers and promotes tumor cell proliferation, tumorigenicity, and metastasis. It is considered a potential therapeutic target and a prognostic marker for poor outcomes in cancer.

Other names: DEP.8SDP35DEPDC1-V2DEPDC1A

Mechanism of action

Silencing or inhibiting DEPDC1 function

Biological functions

Negative regulation of DNA-templated transcriptionCell cycle progressionMotility regulationGTPase activation

Disease associations

Cancer

Biomarkers

DEPDC1 expression level (prognostic)

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