DEPDC1 antisense RNA 1 (DEPDC1-AS1)

DEPDC1 antisense RNA 1 (DEPDC1-AS1) is a long non-coding RNA transcribed antisense to the DEPDC1 gene. It functions primarily as a regulator of gene expression at the RNA level, acting as a scaffold molecule for RNA-binding proteins such as HuR, and thereby modulating the stability and translation of specific mRNAs, for example F11R in gastric cancer cells[1][2][4][5]. DEPDC1-AS1 is overexpressed in multiple tumor types, including gastric, lung, ovarian, and breast cancers, and its high expression is consistently linked to enhanced cell proliferation, migration, and poor clinical prognosis, particularly in gastric cancer[1][4][5]. DEPDC1-AS1 does not directly encode a protein and is not considered a traditional therapeutic target such as an enzyme or receptor, but it is studied as a prognostic biomarker in oncology because of its regulatory role in cancer progression[1][4][5]. No drugs are currently known to interact specifically with DEPDC1-AS1, and its mechanisms of action are distinct from classic drug targets: it acts mainly by modulating RNA-protein interactions involved in mRNA stability[4][5].

Other names

DEPDC1-AS1DEPDC1 antisense long non-coding RNA