DEPDC5-YWHAH readthrough

The DEPDC5-YWHAH readthrough transcript (ENSG00000285404) is an **atypical, non-canonical RNA product** arising from continued transcription across the boundary of the DEPDC5 and YWHAH genes, both located on chromosome 22q12[1][4]. Readthrough transcripts sometimes encode novel fusion proteins or non-coding RNAs, but in this case, there is no evidence that a stable, functional protein is produced from this transcript, nor is there verified literature on its molecular function, disease role, or therapeutic targeting. DEPDC5 is involved in intracellular **signal transduction** and mTOR pathway regulation, with variants associated with focal epilepsy and cancer; YWHAH is a member of the **14-3-3 protein family** involved in regulation of signal transduction via phosphoserine binding[1][3][4][5]. No clear biological or clinical relevance has been established for the readthrough transcript itself. Key issues: - This entity is not a well-characterized or therapeutically relevant protein/receptor. - Structured data for this readthrough transcript is largely missing; scientific and clinical information is focused on the individual DEPDC5 and YWHAH genes. - Curation should default to the functions and disease roles associated with DEPDC5 and YWHAH, not the readthrough transcript. If seeking therapeutic targets, refer to the **individual roles of DEPDC5 (e.g., mTOR pathway regulator) and YWHAH (e.g., signal transduction adaptor)** rather than the readthrough fusion[1][3][4][5].

Other names

DEPDC5-YWHAH fusion transcriptEnsembl ID: ENSG00000285404Readthrough transcriptSometimes referenced as DEPDC5-YWHAH in transcript databases