Der1-like domain family, member 2 pseudogene (ENSG00000231923)

This entry refers to a **pseudogene**—a genomic DNA sequence similar to a functional gene (in this case, the Der1-like domain family, probably DERL2), but which lacks the ability to encode a functional protein[1][2][4][6]. Pseudogenes often arise by gene duplication or retrotransposition, but due to mutations (such as frameshifts or premature stop codons), they are not transcribed or translated into functional proteins[4]. While the protein-coding relatives of this family, such as Derlin-1 and Derlin-2, are involved in endoplasmic reticulum-associated degradation (ERAD) and protein quality control, **pseudogenes themselves do not participate directly in these functions**[1][4]. There are no established biological functions, disease associations, biomarkers, or drugs related to this specific pseudogene. Inclusion of this entry as a therapeutic target is **incorrect**, as pseudogenes are not considered druggable or functional targets in standard pharmacological or clinical contexts[2][4][6]. Summary: ENSG00000231923 (Der1-like domain family, member 2 pseudogene) is a nonfunctional sequence related to the derlin/DERL protein family and is not a therapeutic or biological target[1][2][4].

Other names

DERL2 pseudogeneDerlin 2 pseudogeneDerlin-like 2 pseudogene