Derlin-3 (DERL3)

Derlin-3 is an endoplasmic reticulum (ER) membrane protein belonging to the derlin family, critically involved in the process of ER-associated protein degradation (ERAD)[1][2][4][5]. It resides in the ER and facilitates the retrotranslocation and degradation of misfolded lumenal glycoproteins, maintaining cellular homeostasis and allowing cells to adapt to ER stress[1][2][4]. Derlin-3 expression and participation in the composition of ERAD complexes is tissue-specific and especially critical under ER stress, where it helps switch complex partners to modulate proteostasis[1]. Deficiency or malfunction of Derlin-3 leads to accumulation of misfolded proteins and is implicated in several diseases, especially cancers such as gastric cancer (where it is a tumor suppressor and methylation biomarker)[3][4]. It works in concert with other ERAD factors including Derlin-1, Derlin-2, Herp, HRD1, SEL1L, and VCP/p97[1][2][4], but currently is not a direct drug target with known approved interventions.

Other names

Derlin-3DERL3C22orf14DER3LLN2FLJ43842MGC71803IZP6Der1-like protein 3Der1-like domain family member 3degradation in endoplasmic reticulum protein 3DERtrin-3

For potential drugs: Would target ERAD dysfunction by modulating retrotranslocation of misfolded glycoproteins and protein quality control mechanisms. No approved drugs listed.