Dermal and epidermal cells

Dermal and epidermal cells represent the complex cellular architecture of the skin, organized into two primary layers: the outer epidermis and the underlying dermis. The epidermis is predominantly composed of keratinocytes that undergo terminal differentiation to form the stratum corneum, providing a vital permeability barrier against pathogens and dehydration (Source: StatPearls, Anatomy, Skin). The dermis consists of fibroblasts, which synthesize the extracellular matrix, along with various immune cells, blood vessels, and nerves that provide structural and nutritional support (Source: NIH, Skin Health and Diseases). While these cells are the focus of dermatological pharmacology, they are classified as a tissue or cell population rather than a discrete molecular target like a single protein or enzyme. Therapeutic agents targeting these cells are used to treat a wide array of conditions, including inflammatory diseases like psoriasis, infections, and malignancies, often by interacting with specific molecular pathways such as the JAK/STAT or MAPK signaling cascades (Source: PubMed, Dermatological Therapies).

Other names

Skin cellsCutaneous cellsEpidermal keratinocytes and dermal fibroblasts

Drugs targeting these cells typically act by modulating intracellular signaling pathways, such as the glucocorticoid or retinoic acid receptor pathways, or by inhibiting specific cytokines and growth factors that regulate cell proliferation and inflammation.