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Dermatan Sulfate

Molecular classification
Glycosaminoglycan, Polysaccharide
01

Overview

Dermatan sulfate is a naturally occurring glycosaminoglycan (GAG) found predominantly in the skin, blood vessels, heart valves, tendons, lungs, and intestinal mucosa. It is composed of repeating disaccharide units of N-acetylgalactosamine (GalNAc) and L-iduronic acid (IdoA). It plays roles in extracellular matrix construction, blood coagulation regulation, and wound repair. It is not considered a therapeutic target in the conventional sense but is under investigation for its antithrombotic, antiviral, and anticancer properties.

Other names
Chondroitin Sulfate Bbeta-HeparinDermatan sulphate
02

Biological functions

ECM construction and maintenanceInteraction with collagens and growth factorsRegulation of blood coagulationWound repairCell differentiationMorphogenesisCell migrationTissue development
03

Disease associations

Cardiovascular diseaseTumorigenesis/Cancer progressionInfectionFibrosisSpondylo-dysplastic Ehlers-Danlos syndrome

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