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Target intelligence / Profile preview
Dermatophagoides pteronyssinus allergen Der p 1 (Der p 1)
- Target
- Der p 1
- Molecular classification
- Enzyme, Cysteine protease, Allergen
01
Overview
Der p 1 is a major allergen produced by the house dust mite Dermatophagoides pteronyssinus. It is a cysteine protease that disrupts epithelial barriers and induces inflammatory responses, contributing to allergic diseases such as asthma and allergic rhinitis.
- Other names
- Group 1 allergenDer p IMajor dust mite allergen Der p 1
02
Mechanism of action
Proteolytic cleavage of epithelial tight junction proteins and immune cell surface receptors; activation of protease-activated receptors.
03
Biological functions
ProteolysisDigestion (in mites)Epithelial barrier disruptionCytokine inductionImmune response modulationAllergenicity
04
Disease associations
Allergic rhinitisAsthmaAllergy
05
Safety considerations
Potential for anaphylaxisExacerbation of allergic symptoms
06
Interacting drugs
Allergen immunotherapy
1 more in the full profile.
07
Biomarkers
IgE levelsDer p 1-specific IgE
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