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Target intelligence / Profile preview
Dermokine (DMKN)
- Target
- DMKN
- Molecular classification
- Other (Secreted protein)
01
Overview
Dermokine (DMKN) is a secreted protein primarily expressed in epithelial tissues, particularly in the differentiated layers of skin. It is implicated in the regulation of keratinocyte differentiation, cornified envelope assembly, and endosomal trafficking through Rab5. Multiple isoforms of dermokine exist, arising from alternative splicing, and its expression is upregulated in inflammation. Mutations or dysregulation of DMKN are associated with certain inflammatory and keratinization disorders in humans[1][2][4][5][6].
- Other names
- DermokineDMKNUNQ729/PRO1411ZD52F10Epidermis-specific secreted protein SK30Epidermis-specific secreted protein SK89UNQ729
02
Biological functions
Soluble regulator of keratinocyte differentiationInvolved in cornified envelope assemblyRegulator of early endosomal trafficking (via Rab5 interaction for DMKN-delta isoform)[1][4][5][6]
03
Disease associations
Inflammatory bowel disease 14Ichthyosis vulgarisPotential involvement in skin diseases linked to keratinocyte differentiation[1][2]
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