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Target intelligence / Profile preview
DERPC proline and glycine rich nuclear protein (DERPC)
- Target
- DERPC
- Molecular classification
- Nuclear protein, Carrier protein, Tumor suppressor protein, Other
01
Overview
DERPC proline and glycine rich nuclear protein is a strongly basic, proline- and glycine-rich protein localized to the nucleus. It has been identified as ubiquitously expressed, with higher levels in several tissues and moderate in prostate. Importantly, DERPC expression is significantly decreased in renal (67%) and prostate (33%) tumors, supporting its putative role as a tumor suppressor. Experimental overexpression of DERPC inhibits prostate tumor cell growth and alters nuclear morphology, highlighting its significance in cell division and the regulation of gene expression. However, DERPC is still under basic research, and neither drugs nor direct therapeutic applications are available at present.
- Other names
- Decreased expression in renal and prostate cancer proteinDecreased expression in renal and prostate cancerProtein DERPCChromosome transmission fidelity protein 8 homolog
02
Biological functions
Inhibition of cell proliferation/tumor cell growthPotential regulation of nuclear morphologyUbiquitous tissue expression with higher levels in kidney, skeletal muscle, testis, liver, ovary, heart; moderate in prostateImplicated in cell division and gene expression regulation
03
Disease associations
Cancer (particularly renal and prostate cancer, where its expression is decreased)Potential tumor suppressor activity
04
Biomarkers
Decreased DERPC expression is a potential biomarker for renal and prostate cancer diagnosis and prognosis
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