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Target intelligence / Profile preview
Desmoglein 3 (DSG3)
- Target
- DSG3
- Molecular classification
- Cadherin superfamily, Desmosomal cadherin, Transmembrane glycoprotein
01
Overview
Desmoglein 3 (DSG3) is a calcium-binding transmembrane glycoprotein that serves as a core component of desmosome junctions in vertebrate epithelial cells. It mediates calcium-dependent cell-cell adhesion and functions as a surface regulator for various intracellular signaling pathways. DSG3 plays a crucial role in cell proliferation, differentiation, migration, apoptosis, tissue integrity, and homeostasis. It is a major autoantigen in pemphigus vulgaris and serves as a prognostic marker for Esophageal Squamous Cell Carcinoma (ESCC).
02
Mechanism of action
Modulation of cell-cell adhesion and intracellular signaling pathways.
03
Biological functions
Cell adhesionStructural supportSignalingPositive regulation of cellular adhesionStress response regulation
04
Disease associations
Pemphigus VulgarisEsophageal Squamous Cell Carcinoma (ESCC)Arrhythmogenic Cardiomyopathies
05
Safety considerations
Autoimmune response (Pemphigus Vulgaris)Potential involvement in cancer progression
06
Biomarkers
Prognostic marker for Esophageal Squamous Cell Carcinoma (ESCC)
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