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Detoxification Process
- Molecular classification
- Other[4][9]
01
Overview
"Detoxification process" is not a single molecule, receptor, enzyme, or drug target; it is a broad physiological and sometimes clinical concept describing the removal or neutralization of toxic substances from the body, largely via hepatic Phase I (e.g., cytochrome P450) and Phase II (conjugation: glucuronidation, sulfation, glutathione conjugation, acetylation, methylation, amino acid conjugation) pathways that convert lipophilic compounds to water-soluble metabolites for excretion by bile, kidneys, and intestines, with additional usage in medicine for managing acute intoxication and withdrawal; therefore it should not be treated as a discrete therapeutic target entry[4][9][5][3][10].
- Other names
- DetoxificationDetoxDetoxicationMetabolic detoxificationLiver detoxificationPhase I and Phase II detoxification pathways[4][9]
02
Biological functions
Xenobiotic metabolismBiotransformationRedox homeostasisToxin eliminationDrug metabolismAntioxidant defense[4][9][5]
03
Disease associations
Other (general role in toxic exposures, addiction withdrawal contexts, hepatic/renal failure contexts)[4][10][8]
04
Safety considerations
“Detox” diets/cleanses lack evidence and can be misleading or risky when substituting for medical care[8][6].Impairment of physiological detoxification occurs in liver or kidney failure, sometimes requiring dialysis or transplantation[4].
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