Detrusor smooth muscle of bladder

The **detrusor smooth muscle** is the main muscular component of the urinary bladder wall. It is responsible for both storing urine by relaxing during filling and expelling urine by contracting during micturition. The detrusor's function is regulated by complex interactions between nervous system inputs—primarily parasympathetic stimulation for contraction—and hormonal signals. The tissue contains multiple receptor types that mediate these responses, including muscarinic acetylcholine receptors and beta-adrenoceptors[1][4]. Dysfunction or pathological changes in this muscle are implicated in several urological conditions such as overactive bladder syndrome, lower urinary tract symptoms (LUTS), and bladder outlet obstruction[1]. **Note:** "Smooth muscle of bladder" refers to a tissue type rather than a specific molecular target such as a receptor or enzyme. Therefore, it does not fit the definition of a canonical therapeutic target molecule; instead, it is an anatomical/functional structure composed primarily of contractile cells expressing various molecular targets[1][3]. For drug development or mechanistic studies, more precise targets would be individual proteins/receptors within this tissue—such as muscarinic M2/M3 receptors or KV7 potassium channels—rather than the entire smooth muscle itself. If you require structured information on specific molecular targets within the detrusor/bladder smooth muscle (e.g., "Muscarinic acetylcholine receptor M3"), please specify further.

Other names

Bladder smooth muscleUrinary bladder detrusor muscleDetrusor muscle

Inhibition of muscarinic receptors to reduce involuntary contractions Activation of beta-3 adrenergic receptors to promote relaxation