Target intelligence / Profile preview

Deubiquitinase (DUB)

Target: DUB
Molecular classification: Enzyme, Protease, Cysteine Protease, Metalloprotease

Overview

Deubiquitinases (DUBs) are a large and diverse group of proteases that remove ubiquitin moieties from proteins. They play essential roles in maintaining cellular homeostasis by regulating protein stability, cell signaling pathways, gene expression, and other cellular processes. Dysregulation of DUBs has been implicated in various diseases, including cancer and neurodegenerative disorders, making them attractive therapeutic targets.

Other names: Deubiquitinating enzyme

Mechanism of action

Inhibition of deubiquitinase activity

Biological functions

Protein turnover/degradation regulationSignal transductionGene expressionProtein quality controlDNA damage repairCell cycle progressionRegulation of ubiquitination

Disease associations

CancerNeurodegenerative diseaseOther

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