Dexamethasone-induced Ras-related protein 1 (RASD1)

Dexamethasone-induced Ras-related protein 1 (RASD1) is a member of the Ras superfamily of small GTPases, acting as a guanine nucleotide exchange factor (GEF) for Gi proteins and regulating multiple cellular signals that impact growth, hormone responses, and neuronal excitability. RASD1 is ubiquitously expressed but is particularly enriched in the brain and endocrine tissues, where it serves key regulatory roles at the interface of glucocorticoid and adrenocorticotropic hormone (ACTH) signaling. The gene is rapidly inducible by dexamethasone and other corticosteroids, attributed to a glucocorticoid response element within its promoter. RASD1 participates in cellular stress responses, activation and inhibition of ion channels (notably TRPC4), and transcriptional regulation via protein-protein interactions (CAPON, FE65). Alterations in its expression or function impact diseases ranging from cancer to stress-related endocrine disorders, and its inactivation can lead to drug resistance in some hematologic cancers.

Other names

RASD1AGS1DEXRAS1ras related dexamethasone induced 1MGC:26290

Drugs such as dexamethasone induce RASD1 expression through glucocorticoid response elements, modulating downstream G-protein signaling and signal transduction pathways.