DExH-box helicase 9 (DHX9)

DHX9 is a member of the DExH-box family of RNA and DNA helicases. It is an NTP-dependent enzyme that catalyzes the unwinding of both double-stranded DNA and RNA as well as hybrid structures such as R-loops and G-quadruplexes. The protein plays central roles in multiple aspects of nucleic acid metabolism, including transcription, translation, replication, splicing, microRNA biogenesis, transport, and DNA repair. DHX9 is overexpressed in several cancer types; depletion leads to antiproliferative effects on various cancer cell lines. Mutations or dysregulation can also contribute to neurological disorders due to its essential role in neuronal RNA metabolism.

Other names

ATP-dependent RNA helicase ANuclear DNA helicase IIRNA helicase A

ATP-dependent unwinding of DNA and RNA duplexes, resolution of R-loops, D-loops, triplex DNA, and G-quadruplexes.