DHRS4 antisense RNA 1 (DHRS4-AS1)

DHRS4 antisense RNA 1 (DHRS4-AS1) is a long noncoding natural antisense transcript located head-to-head with the DHRS4 protein-coding gene. It regulates the DHRS4 gene cluster (including DHRS4, DHRS4L2, DHRS4L1) through epigenetic mechanisms such as histone deacetylation and methylation, and by recruiting chromatin modifiers (G9a, EZH2) and DNA methyltransferases. DHRS4-AS1 is implicated in cancer, notably acting as a tumor suppressor in osteosarcoma by suppressing cell proliferation and inducing apoptosis through a microRNA-dependent pathway (e.g., modulates the miR-362-5p/NPEPPS axis)[1][3][4]. Its regulatory functions extend to chromatin structure, gene silencing, and potentially other processes tied to its expression profile in normal and cancerous cells. If further nomenclature issues arise: The supplied abbreviation "ENSG00000308027" does not match standard ENSG (Ensembl Gene) identifiers—these typically have seven digits. It may be a typographical error or a database-specific reference; the molecule described here matches all known properties of DHRS4 antisense RNA 1 (DHRS4-AS1)[1][3][4].

Other names

AS1DHRS4natural antisense transcript to DHRS4DHRS4-AS1C14ORF167-associated antisense

Epigenetic silencing via chromatin modification (interaction with histone methyltransferases G9a and EZH2, leading to H3K9me2 and H3K27me3 modifications); DNA methylation by recruiting DNA methyltransferases; Competing endogenous RNA (ceRNA) mechanism: acts as a sponge for miR-362-5p and thus regulates aminopeptidase puromycin sensitive (NPEPPS)