Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Diacylglycerol Acyltransferase 2 (DGAT2)
- Target
- DGAT2
- Molecular classification
- Enzyme, Acyltransferase
01
Overview
Diacylglycerol acyltransferase-2 (DGAT2) is an integral membrane protein and a key enzyme in lipid metabolism. It catalyzes the final step in the synthesis of triacylglycerol (TG), a major form of energy storage in eukaryotic cells, by covalently attaching a fatty acyl-CoA to diacylglycerol. This reaction is essential for lipid droplet formation and energy homeostasis. Abnormal expression or activity has been linked to metabolic disorders such as obesity, hepatic steatosis (fatty liver disease), insulin resistance, and cardiovascular diseases due to altered lipid accumulation or mobilization.
02
Mechanism of action
Inhibition of diacylglycerol acyltransferase 2, leading to reduced triglyceride synthesis.
03
Biological functions
Triglyceride synthesisLipid storageEnergy homeostasis
04
Disease associations
ObesityHepatic steatosisInsulin resistanceCardiovascular diseases
05
Safety considerations
Potential for dyslipidemiaEffects on hepatic lipid metabolism
Beyond the preview
Go deeper on Diacylglycerol Acyltransferase 2 (DGAT2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Diacylglycerol Acyltransferase 2 (DGAT2).