Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Diacylglycerol kinase (DGK or DAGK)
- Target
- DGK or DAGK
- Molecular classification
- Enzyme, Kinase
01
Overview
Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the ATP-dependent phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PA). This reaction plays a crucial role in cellular signaling by regulating the levels of two important bioactive lipids: DAG and PA, both of which act as second messengers in various signal transduction pathways. DGKs serve as molecular switches, terminating DAG-mediated signaling while simultaneously activating PA-mediated pathways. There are at least ten known mammalian isoforms of DGK with tissue-specific expression patterns and regulatory roles. Targeted modulation of specific DGK isoforms is being explored for diseases involving aberrant lipid signaling—including neuronal disorders and cancer immunotherapy applications.
- Other names
- DAG kinase
02
Mechanism of action
ATP-dependent phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PA)
03
Biological functions
Signal transductionLipid metabolismImmune regulationRegulation of DAG and PA levelsMembrane biosynthesis
04
Disease associations
CancerAutoimmunityNeuronal disordersImmunodeficiencyHyper-responsivenessAberrant lipid signaling
05
Safety considerations
Potential for hyper-responsiveness or autoimmunity with DGK inhibitionPotential for unintended effects on lipid signaling pathways
Beyond the preview
Go deeper on Diacylglycerol kinase (DGK or DAGK).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Diacylglycerol kinase (DGK or DAGK).