Diacylglycerol kinase iota (DGKI)

Diacylglycerol kinase iota is an enzyme that phosphorylates the lipid messenger diacylglycerol (DAG) to produce phosphatidic acid (PA), regulating the respective levels of these two important bioactive lipids[2][3][5][6][7]. This activity is central to lipid metabolism and signal transduction in eukaryotic cells[1][2][3][6]. DGKI belongs to a conserved family of DGKs characterized by a catalytic domain and multiple cysteine-rich (C1) domains[1][5]. Tissue expression studies show particularly high levels in the brain and retina, suggesting a role in the central nervous system and visual processing[4][5]. Dysregulation of diacylglycerol kinase enzymes, including DGKI, has been connected to cancer and metabolic diseases[1]. The human protein is encoded by the DGKI gene.

Other names

DGK-iotaDGKIDiacylglycerol kinase iota (human)diglyceride kinase iotaDGKι