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Target intelligence / Profile preview
Diacylglycerol kinase zeta (DGKζ)
- Target
- DGKζ
- Molecular classification
- Enzyme, Eukaryotic diacylglycerol kinase family
01
Overview
Diacylglycerol kinase zeta (DGKζ) is an enzyme that phosphorylates diacylglycerol (DAG) to produce phosphatidic acid (PA), thereby regulating the intracellular levels of these two bioactive lipids. It plays a critical role in immune cell signaling, particularly in T-cell receptor (TCR) signaling, acting as a negative regulator. DGKζ resides primarily in the cytosol and translocates to the plasma membrane upon stimulation. Alternative splicing leads to different isoforms with distinct regulatory functions.
- Other names
- DAG kinase zetaDiglyceride kinase zeta2.7.1.107DGK-zetaDAGK6hDGKzeta[6]
02
Mechanism of action
Phosphorylates diacylglycerol (DAG) to produce phosphatidic acid (PA).
03
Biological functions
Signal transductionLipid metabolismRegulation of DAG and PA levels
04
Disease associations
Immune dysregulation
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