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Target intelligence / Profile preview
Diacylglycerol O-acyltransferase 1 (DGAT1)
- Target
- DGAT1
- Molecular classification
- Enzyme, Acyltransferase, Transmembrane protein
01
Overview
Diacylglycerol O-acyltransferase 1 (DGAT1) is a key enzyme that catalyzes the final step in triacylglycerol (TAG) synthesis: the conversion of diacylglycerol (DAG) and fatty acyl-CoA to triacylglycerol. It is essential for fat storage, energy metabolism, and lipid homeostasis. Loss-of-function mutations are associated with congenital diarrheal disorders due to defective fat absorption. DGAT1 inhibitors are being explored as therapeutic agents for treating obesity-related conditions and other metabolic disorders.
- Other names
- ARATARGP1DIAR7DGAT
02
Mechanism of action
Inhibition of diacylglycerol O-acyltransferase 1, reducing triacylglycerol synthesis.
03
Biological functions
Triacylglycerol biosynthesisAcyl-CoA:retinol acyltransferase activityLipid storageEnergy metabolismVitamin A esterification
04
Disease associations
ObesityInsulin resistanceNon-alcoholic fatty liver diseaseCongenital diarrheal disorders
05
Safety considerations
Potential for altered lipid metabolismPossible gastrointestinal side effects
06
Interacting drugs
DGAT1-IN-1
1 more in the full profile.
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