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Hepatic diacylglycerol acyltransferase 2 (None)
- Target
- None
- Molecular classification
- Enzyme, Acyltransferase
01
Overview
Hepatic diacylglycerol acyltransferase 2 (DGAT2) is a key enzyme involved in triglyceride synthesis, particularly within the liver. It catalyzes the final step of triglyceride formation by transferring an acyl group from acyl-CoA to diacylglycerol, resulting in the production of triacylglycerol (triglyceride). Its inhibition reduces hepatic steatosis without causing harmful side effects like increased inflammation or impaired glucose handling. Both small-molecule drugs and RNAi approaches are being developed to target this enzyme therapeutically against NAFLD/NASH.
- Other names
- DGAT2Diacylglycerol O-acyltransferase 2
02
Mechanism of action
Inhibition of DGAT2 reduces hepatic triglyceride synthesis and lipid accumulation in hepatocytes.
03
Biological functions
Triglyceride biosynthesisLipid metabolismEnergy storage
04
Disease associations
Nonalcoholic fatty liver disease (NAFLD)Nonalcoholic steatohepatitis (NASH)Hepatic steatosisMetabolic syndrome
05
Safety considerations
Potential for off-target effectsLong-term effects of DGAT2 inhibition need further study
06
Interacting drugs
PF-06427878
1 more in the full profile.
07
Biomarkers
Liver fat content (MRI)Markers of liver function
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