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Target intelligence / Profile preview
Spermidine/spermine N1-acetyltransferase 1 (SSAT)
- Target
- SSAT
- Molecular classification
- Enzyme, Transferase, Acetyltransferase
01
Overview
Spermidine/spermine N1-acetyltransferase 1 (SAT1), also known as diamine acetyltransferase 1 or SSAT, is a key enzyme in polyamine metabolism. It catalyzes the N(1)-acetylation of spermidine and spermine, which are essential polyamines involved in cell growth, chromatin structure maintenance, and other cellular functions. SAT1 acts as a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. Alterations in SAT1 activity have been linked to cell growth, cancer, and metabolism. It serves as both a biomarker candidate for disease states like cancer and a potential therapeutic target.
- Other names
- SAT1Diamine acetyltransferase 1SSAT-1DC21KFSDKFSDXSAT
02
Mechanism of action
Acetylation of spermidine and spermine
03
Biological functions
Polyamine metabolismRegulation of intracellular polyamine homeostasisCell growth regulationDNA stabilizationGene expression regulation
04
Disease associations
CancerMetabolic disordersObesityGlucose intoleranceOxidative stress
05
Safety considerations
Dysregulation may contribute to tumor progression/metastasisManipulation can affect cell proliferation and metabolic state
06
Interacting drugs
NSAIDs (nonsteroidal anti-inflammatory drugs)
1 more in the full profile.
07
Biomarkers
SAT1 expression levels in cancerPolyamine levels
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