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Diaphanous Inhibitory Domain–Diaphanous Autoregulatory Domain Interaction
- Molecular classification
- Protein-Protein Interaction, Formins, Diaphanous-related formins
01
Overview
The interaction between the diaphanous inhibitory domain (DID) and the diaphanous autoregulatory domain (DAD) is a key regulatory mechanism in diaphanous-related formins (DRFs). This interaction maintains DRFs in an autoinhibited state, preventing FH2-mediated actin polymerization, until activation by upstream signals like Rho GTPases. Disruption of this interaction leads to the activation of DRFs and subsequent actin polymerization, influencing cell shape, migration, division, and development. DRFs also coordinate microtubule stabilization.
02
Mechanism of action
Inhibition of DID-DAD interaction to activate Formins.
03
Biological functions
Actin filament nucleationActin filament elongationRegulation of actin cytoskeletonCell morphologyCell migrationCell divisionMicrotubule stabilization
04
Disease associations
Hearing loss syndromesThrombocytopenia
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