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Target intelligence / Profile preview
Dicer Substrate (DsiRNA)
- Target
- DsiRNA
- Molecular classification
- dsRNA, siRNA, miRNA substrate, RNA
01
Overview
A Dicer substrate is a double-stranded RNA molecule designed or naturally occurring as a target for cleavage by the Dicer enzyme. Synthetic Dicer-substrate siRNAs (DsiRNAs) are engineered for optimal processing, resulting in efficient gene silencing. They are typically 25-27 base pairs in length and are processed into siRNAs that guide RISC to target mRNA for degradation.
- Other names
- Synthetic Dicer-substrate siRNAsDsiRNAsdsRNA Dicer SubstratesiRNA Dicer Substrate
02
Mechanism of action
Dicer substrates are processed by Dicer into siRNAs, which are then loaded onto the RISC complex to target and cleave mRNA molecules, leading to gene silencing.
03
Biological functions
RNA interferenceGene silencingPost-transcriptional gene regulation
04
Disease associations
Cancer (potential)Viral infection (defense)Genetic disorders (potential)
05
Safety considerations
Off-target effectsImmune stimulationDelivery challenges
06
Interacting drugs
Synthetic siRNAs
1 more in the full profile.
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