Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Dickkopf-related protein 1 (DKK1)
- Target
- DKK1
- Molecular classification
- Secreted glycoprotein, Dickkopf (DKK) family member
01
Overview
Dickkopf-related protein 1 (DKK1) is a secreted glycoprotein that acts as an antagonist of the Wnt/β-catenin signaling pathway. It inhibits Wnt signaling by binding to LRP5/6 co-receptors, preventing downstream activation. DKK1 plays critical roles in embryonic development, bone homeostasis, and is implicated in various diseases including cancer, bone disorders, and cardiovascular disease. It is being investigated as a therapeutic target, particularly in oncology and immunotherapy, with anti-DKK1 antibodies showing promise in preclinical studies.
02
Mechanism of action
DKK1 binds to LRP5/6 co-receptors, preventing activation of downstream Wnt signaling events. Anti-DKK1 antibodies neutralize DKK1, promoting Wnt signaling and potentially reducing immune suppression.
03
Biological functions
Wnt/β-catenin signaling pathway antagonistEmbryonic developmentBone homeostasisRegulation of PAI-1 expressionImmunomodulation
04
Disease associations
CancerBone disordersCardiovascular diseaseRheumatoid arthritis
05
Safety considerations
Potential disruption of Wnt signaling in normal tissuesImmunogenicity of antibody-based therapies
06
Interacting drugs
Anti-DKK1 antibodies (e.g., DKN-01)
07
Biomarkers
Elevated DKK1 levels in cancer (prostate, pancreatic)Elevated DKK1 levels in multiple myeloma
Beyond the preview
Go deeper on Dickkopf-related protein 1 (DKK1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Dickkopf-related protein 1 (DKK1).