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Target intelligence / Profile preview
Dickkopf-related protein 3 (DKK3)
- Target
- DKK3
- Molecular classification
- Secreted glycoprotein, Dickkopf family member
01
Overview
Dickkopf-related protein 3 (DKK3) is a secreted glycoprotein and a member of the Dickkopf (DKK) family. It plays a complex role in modulating the Wnt signaling pathway, with context-dependent effects on tumor suppression/promotion. DKK3 is also involved in developmental processes, tissue homeostasis, immunomodulation, and kidney disease.
02
Mechanism of action
Epigenetic reactivation, gene therapy, blockade of DKK3, modulation of Wnt signaling pathway
03
Biological functions
Wnt signaling modulationDevelopmental regulationStem cell differentiationTissue homeostasisImmunomodulation
04
Disease associations
Cancer (tumor suppressor/oncogene)Kidney diseaseFibrosis
05
Safety considerations
Context-dependent role in cancer (tumor suppressor vs. oncogene)Potential for off-target effects on Wnt signaling
06
Biomarkers
DKK3 expression levels in cancerDKK3 levels in kidney disease
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