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Target intelligence / Profile preview
Differentiation Antigen A33 (GPA33)
- Target
- GPA33
- Molecular classification
- Cell surface glycoprotein, Immunoglobulin superfamily
01
Overview
Differentiation Antigen A33 (GPA33) is a cell surface glycoprotein belonging to the immunoglobulin superfamily. It is highly expressed on the basolateral surfaces of epithelial cells in the small intestine and colon, as well as in a high percentage of colorectal, gastric, and pancreatic cancers. Due to its restricted expression profile and high prevalence in colorectal cancer, A33 serves as an attractive target for antibody-based therapies, including radioimmunotherapy and bispecific T-cell engager antibodies.
- Other names
- Glycoprotein A33A33 Antigen
02
Mechanism of action
Antibody-dependent cell cytotoxicity (ADCC) via bispecific antibodies; targeted delivery of radiation via radiolabeled antibodies.
03
Biological functions
Cell adhesionCell-cell interactionDifferentiation antigen (suggested)
04
Disease associations
Cancer
05
Safety considerations
On-target, off-tumor toxicity in normal colon/small intestineImmunogenicity of antibody-based therapies
06
Biomarkers
Colorectal cancerGastric cancerPancreatic cancer
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