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Digoxin
- Molecular classification
- Cardiac glycoside, Inotropic agent, Group V antiarrhythmic
01
Overview
Digoxin is a cardiac glycoside medication used to treat heart failure and atrial fibrillation. It inhibits the Na+/K+ ATPase pump, leading to increased intracellular calcium and enhanced myocardial contractility. It also slows conduction through the AV node, helping to control heart rate. Digoxin has a narrow therapeutic window and requires careful monitoring due to the risk of toxicity.
- Other names
- LanoxinDigitekDigoxLanoxicapsCardoxin
02
Mechanism of action
Reversibly inhibits the sodium-potassium ATPase (Na+/K+ ATPase) enzyme in cardiac myocytes, leading to increased intracellular sodium and calcium concentrations, resulting in enhanced myocardial contractility and slowed conduction through the AV node.
03
Biological functions
Increases myocardial contractilityControls heart rateInhibits Na+/K+ ATPase
04
Disease associations
Heart failureAtrial fibrillation
05
Safety considerations
Narrow therapeutic windowRisk of toxicityArrhythmiasElectrolyte imbalancesRenal impairmentGastrointestinal disturbancesVisual changesConfusionBradycardia
06
Interacting drugs
Drugs affecting potassium levels
3 more in the full profile.
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