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Target intelligence / Profile preview
Digoxin-Sensitive Sodium-Potassium ATPase (Na⁺/K⁺-ATPase)
- Target
- Na⁺/K⁺-ATPase
- Molecular classification
- Enzyme, Transporter, Ion Transporter, P-type ATPase
01
Overview
The digoxin-sensitive sodium-potassium ATPase (Na⁺/K⁺-ATPase) is a transmembrane enzyme essential for maintaining cellular ion gradients. It actively transports sodium and potassium ions against their concentration gradients using ATP, playing a critical role in resting membrane potential, cell volume regulation, secondary active transport, and signal transduction. Cardiac glycosides like digoxin inhibit this enzyme, increasing intracellular calcium and enhancing cardiac contractility.
- Other names
- Sodium-Potassium ATPaseSodium-Potassium Pump
02
Mechanism of action
Inhibition of Na⁺/K⁺-ATPase leading to increased intracellular Na+ and Ca²+, enhancing cardiac contractility.
03
Biological functions
Maintenance of resting membrane potentialRegulation of cellular volumeSecondary active transportSignal transductionIon transport
04
Disease associations
Cardiovascular diseaseArrhythmiasNeurological disorders
05
Safety considerations
ArrhythmiasMuscle weakness/paralysisAltered neuronal excitabilityDigoxin toxicity
06
Interacting drugs
Digoxin
1 more in the full profile.
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