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Dihydrofolate Synthetase (DHFS)
- Target
- DHFS
- Molecular classification
- Enzyme, Ligase
01
Overview
Dihydrofolate synthetase (DHFS) is an enzyme that catalyzes the ATP-dependent ligation of L-glutamate to 7,8-dihydropteroate, forming 7,8-dihydropteroylglutamate (dihydrofolate). This enzyme is a key component of the folic acid biosynthesis pathway in bacteria and is absent in mammals, making it a validated target for antimicrobial drug discovery. Inhibition of DHFS disrupts folate synthesis, which is essential for nucleotide synthesis and amino acid metabolism, leading to bacterial cell death.
- Other names
- Dihydrofolate synthaseH2-folate synthetaseFolylpoly-(gamma-glutamate) synthetase–dihydrofolate synthase7,8-dihydropteroate:L-glutamate ligase (ADP-forming)
02
Mechanism of action
Inhibition of dihydrofolate synthetase
03
Biological functions
Folic acid biosynthesisGlutamate ligationCofactor biosynthesis
04
Disease associations
Infection
05
Interacting drugs
Dihydrohomopteroate
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