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Target intelligence / Profile preview
Dihydrolipoyl acetyltransferase (DLAT)
- Target
- DLAT
- Molecular classification
- Enzyme, Acetyltransferase, Pyruvate Dehydrogenase Complex Component
01
Overview
Dihydrolipoyl acetyltransferase (DLAT), also known as the E2 component of the pyruvate dehydrogenase complex (PDC), is a central enzyme that catalyzes the transfer of an acetyl group from hydroxyethyl-lipoamide to coenzyme A, forming acetyl-CoA. It plays a critical role in linking glycolysis to the citric acid (TCA) cycle. The E2 subunit acts as both a catalytic core and a structural scaffold for the PDC.
- Other names
- DLTADihydrolipoamide AcetyltransferaseMitochondrial autoantigen PBC-E2M2 antigen complex 70 kDa subunitPDCE2PDC-E2
02
Mechanism of action
Transfers an acetyl group from hydroxyethyl-lipoamide to coenzyme A, forming acetyl-CoA.
03
Biological functions
CatalysisAcetyl group transferMetabolic processCellular respirationEnergy metabolismLinking glycolysis to citric acid cycle
04
Disease associations
Metabolic disordersLactic acidosisPrimary biliary cirrhosisAutoimmune diseases
05
Safety considerations
Defects can lead to metabolic disorders and lactic acidosisAutoimmune targeting can occur in primary biliary cirrhosis
06
Biomarkers
Antibodies against PDC-E2 (diagnostic marker for primary biliary cirrhosis)
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