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Target intelligence / Profile preview
Dihydroneopterin aldolase (DHNA)
- Target
- DHNA
- Molecular classification
- Enzyme, Lyase, aldehyde-lyase
01
Overview
Dihydroneopterin aldolase is an enzyme involved in the folate biosynthetic pathway, catalyzing the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. It is a promising target for developing antimicrobial drugs due to its absence in mammals, which makes it a selective target for disrupting bacterial metabolism without affecting human cells. The enzyme does not require metal ions or Schiff base formation for catalysis, making it unique among aldolases.
- Other names
- Dihydropteridine glycolaldehyde-lyaseFolB protein
02
Mechanism of action
Inhibition of DHNA activity disrupts folate biosynthesis in bacteria, inhibiting bacterial growth.
03
Biological functions
Folate biosynthesis
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effectsResistance development in bacteria
06
Interacting drugs
Inhibitors targeting DHNA for antimicrobial purposes
07
Biomarkers
Presence of DHNA activityLevels of DHNA substrates and products
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