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Target intelligence / Profile preview
Dihydroorotate Dehydrogenase (DHODH)
- Target
- DHODH
- Molecular classification
- Enzyme, Flavoenzyme
01
Overview
Dihydroorotate dehydrogenase (DHODH) is a mitochondrial enzyme that catalyzes the fourth step in the de novo biosynthesis of pyrimidines, converting dihydroorotate to orotate. This reaction is essential for producing pyrimidine nucleotides, which are critical building blocks for DNA and RNA synthesis. DHODH is a drug target for immunomodulatory and antiproliferative therapies.
02
Mechanism of action
Inhibition of dihydroorotate dehydrogenase, leading to decreased pyrimidine synthesis.
03
Biological functions
Pyrimidine biosynthesisNucleotide synthesisCell proliferationElectron transport chain activity
04
Disease associations
Miller syndromeAutoimmune diseasesCancerParasitic infections
05
Safety considerations
Potential for immunosuppressionTeratogenicity
06
Interacting drugs
Leflunomide
2 more in the full profile.
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