Target intelligence / Profile preview

Dihydropteroate Synthetase

Molecular classification: Enzyme

Overview

Dihydropteroate synthetase (DHPS) is a key enzyme in the folate biosynthesis pathway of Plasmodium species, including *Plasmodium falciparum* and *Plasmodium vivax*, the causative agents of malaria. DHPS catalyzes the condensation of 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) with p-aminobenzoic acid (pABA) to form 7,8-dihydropteroate, a precursor for folate derivatives essential for parasite survival. DHPS is targeted by sulfa drugs such as sulfadoxine and dapsone, and resistance arises due to point mutations in the dhps gene.

Mechanism of action

Competitive inhibition at pABA site

Biological functions

Folate biosynthesis

Disease associations

Infection

Safety considerations

Drug resistance due to point mutations

Interacting drugs

Sulfadoxine

1 more in the full profile.

Biomarkers

dhps genotypes

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