Dihydropyrimidinase like 2 (CRMP-2)

Dihydropyrimidinase like 2 (CRMP-2) is a widely expressed cytosolic phosphoprotein belonging to the collapsin response mediator protein (CRMP) family. It plays a critical role in neuronal development, axonal guidance, and cytoskeletal remodeling by promoting microtubule assembly and mediating Sema3A-induced growth cone collapse. DPYSL2 is implicated in the regulation of neurite outgrowth, synaptic plasticity, and interacts with calcium channels and other cytoskeletal proteins. Genetic variants and aberrant expression of the protein are associated with neurodevelopmental disorders, Alzheimer's disease, schizophrenia, and acute myeloid leukemia, where it is both a prognostic biomarker and a therapeutic target. Mechanistically, certain drugs and small molecules (e.g., homoharringtonine) can bind DPYSL2, altering its function or expression. The protein is regulated at multiple levels, including phosphorylation and other post-translational modifications, influencing its location and interactions in neuronal and cancer cell signaling.

Other names

DPYSL2CRMP-2CRMP2DHPRP2DRP-2DRP2N2A3ULIP-2ULIP2

Small molecule (e.g., HHT) directly binds to the DPYSL2 protein, modulating its function or expression (downregulation seen in AML cell lines after HHT treatment)