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Target intelligence / Profile preview
DIO2 antisense RNA 1 (DIO2-AS1)
- Target
- DIO2-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
DIO2 antisense RNA 1 (DIO2-AS1) is a long non-coding RNA (lncRNA) that is transcribed from the antisense strand of the DIO2 locus. It is classified as a non-protein-coding RNA and is involved in the regulation of gene expression, particularly in the context of cancer biology. In tongue squamous cell carcinoma (TSCC), DIO2-AS1 is downregulated, and its overexpression inhibits cancer cell proliferation, migration, and invasion, suggesting a possible tumor suppressor-type function. Its molecular function is not fully elucidated, but it is not known to interact with drugs, function as a canonical therapeutic target (such as a receptor, enzyme, or transporter), or serve as a validated biomarker or clinical safety concern at this time[2][5].
- Other names
- CTD-2540C19.1DIO2 antisense RNA 1 (non-protein coding)DIO2-AS1
02
Biological functions
Regulation of gene expressionInhibition of cell proliferationInhibition of cell migrationInhibition of cell invasionOther
03
Disease associations
Cancer (notably tongue squamous cell carcinoma/TSCC)Other
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